| IA: Cedar Rapids-Waterloo-Dubuque (Iowa Satellite TV) | | 2 | 2 | KGAN | Programs on CBS include: The Late Late Show with Craig Ferguson, CBS Evening News, CBS Morning News, The Good Wife, The Early Show, Academy of Country Music Awards, Up to the Minute, Flashpoint, and Cold Case. | Local | Local |
| 7 | 7 | KWWL | Programs on NBC include: Babar, Wimbledon, Kentucky Derby, Jacob Two-Two, Preakness Stakes, Law & Order, Meet the Press, Notre Dame home Football games, and Miss USA. | Local | Local |
| 9 | 9 | KCRG | Programs on ABC include: Indianapolis 500 and other Indy Racing League Races, FlashForward, Lost, Happy Town, The Suite Life of Zack and Cody, American Music Awards, Ugly Betty, The Middle, and Just For Laughs. | Local | Local |
| - | 11 | KDIN | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | - | Local |
| 12 | - | KIIN | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | Local | - |
| 20 | 20 | KWKB | Programs on CW include: America's Next Top Model, Life Unexpected, One Tree Hill, Melrose Place, 90210, Supernatural, The Vampire Diaries, Gossip Girl, and The Tyra Banks Show. | Local | Local |
| 28 | 28 | KFXA | Programs on FOX include: NASCAR on Fox, Family Guy, House, NFL on Fox/Fox NFL Sunday, New Year's Eve Live, NAACP Image Awards, The Simpsons, 24, and Hell's Kitchen. | Local | Local |
| IA: Des Moines-Ames (Iowa Satellite TV) | | 5 | 5 | WOI | Programs on ABC include: Indianapolis 500 and other Indy Racing League Races, FlashForward, Lost, Happy Town, The Suite Life of Zack and Cody, American Music Awards, Ugly Betty, The Middle, and Just For Laughs. | Local | Local |
| 8 | 8 | KCCI | Programs on CBS include: The Late Late Show with Craig Ferguson, CBS Evening News, CBS Morning News, The Good Wife, The Early Show, Academy of Country Music Awards, Up to the Minute, Flashpoint, and Cold Case. | Local | Local |
| 11 | 11 | KDIN | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | Local | Local |
| 13 | 13 | WHO | Programs on NBC include: Babar, Wimbledon, Kentucky Derby, Jacob Two-Two, Preakness Stakes, Law & Order, Meet the Press, Notre Dame home Football games, and Miss USA. | Local | Local |
| 17 | 17 | KDSM | Programs on FOX include: NASCAR on Fox, Family Guy, House, NFL on Fox/Fox NFL Sunday, New Year's Eve Live, NAACP Image Awards, The Simpsons, 24, and Hell's Kitchen. | Local | Local |
| 23 | 23 | KCWI | Programs on CW include: America's Next Top Model, Life Unexpected, One Tree Hill, Melrose Place, 90210, Supernatural, The Vampire Diaries, Gossip Girl, and The Tyra Banks Show. | Local | Local |
| - | 39 | KFPX | KFPX (ION) | - | Local |
| IA: Rapid City (Iowa Satellite TV) | | - | 3 | KOTA | Programs on ABC include: Indianapolis 500 and other Indy Racing League Races, FlashForward, Lost, Happy Town, The Suite Life of Zack and Cody, American Music Awards, Ugly Betty, The Middle, and Just For Laughs. | - | Local |
| - | 7 | KEVN | Programs on FOX include: NASCAR on Fox, Family Guy, House, NFL on Fox/Fox NFL Sunday, New Year's Eve Live, NAACP Image Awards, The Simpsons, 24, and Hell's Kitchen. | - | Local |
| - | 9 | KBHE | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | - | Local |
| - | 15 | KCLO | Programs on CBS include: The Late Late Show with Craig Ferguson, CBS Evening News, CBS Morning News, The Good Wife, The Early Show, Academy of Country Music Awards, Up to the Minute, Flashpoint, and Cold Case. | - | Local |
| - | 21 | KNBN | Programs on NBC include: Babar, Wimbledon, Kentucky Derby, Jacob Two-Two, Preakness Stakes, Law & Order, Meet the Press, Notre Dame home Football games, and Miss USA. | - | Local |
| IA: Sioux City (Iowa Satellite TV) | | - | 4 | KTIV | Programs on NBC include: Babar, Wimbledon, Kentucky Derby, Jacob Two-Two, Preakness Stakes, Law & Order, Meet the Press, Notre Dame home Football games, and Miss USA. | - | Local |
| - | 9 | KCAU | Programs on ABC include: Indianapolis 500 and other Indy Racing League Races, FlashForward, Lost, Happy Town, The Suite Life of Zack and Cody, American Music Awards, Ugly Betty, The Middle, and Just For Laughs. | - | Local |
| - | 14 | KMEG | Programs on CBS include: The Late Late Show with Craig Ferguson, CBS Evening News, CBS Morning News, The Good Wife, The Early Show, Academy of Country Music Awards, Up to the Minute, Flashpoint, and Cold Case. | - | Local |
| - | 19 | KXNE | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | - | Local |
| - | 27 | KSIN | Programs on PBS include: Franny's Feet, Thomas and Friends, Great Performances, DragonflyTV, Angelina Ballerina, Washington Week, Ask This Old House, Sesame Street, and Between the Lions. | - | Local |
| - | 44 | KPTH | Programs on FOX include: NASCAR on Fox, Family Guy, House, NFL on Fox/Fox NFL Sunday, New Year's Eve Live, NAACP Image Awards, The Simpsons, 24, and Hell's Kitchen. | - | Local |
|
