| Local Channels (Greenville Direct TV) | | 2 | WDTN | Programs on NBC include: Chuck, Late Night with Jimmy Fallon, Last Call with Carson Daly, Miss Universe, The Olympics through 2012, PGA Tour Golf, Notre Dame home Football games, The Biggest Loser, and Today. | Local |
| 7 | WHIO | Programs on CBS include: CSI: Miami, Emmy Awards, Two and a Half Men, NCIS: Los Angeles, Let's Make a Deal, The Early Show, Criminal Minds, The Bold and the Beautiful, and CBS News Sunday Morning. | Local |
| 16 | WPTD | Programs on PBS include: P.O.V., Animalia, Frontline, Caillou, Martha Speaks, Sid the Science Kid, Antiques Roadshow, Independent Lens, and A Place Of Our Own. | Local |
| 22 | WKEF | Programs on ABC include: That's So Raven, 20/20, The Emperor's New School, World News Now, All My Children, Country Music Association Awards, Academy Awards, Hannah Montana, and Wife Swap. | Local |
| 26 | WBDT | Programs on CW include: The Tyra Banks Show, One Tree Hill, Supernatural, Smallville, Gossip Girl, Life Unexpected, The Vampire Diaries, 90210, and Melrose Place. | Local |
| 45 | WRGT | Programs on FOX include: Bowl Championship Series, New Year's Eve Live, Fringe, The Conan O'Brien Show, The Cleveland Show, Teen Choice Awards, So You Think You Can Dance, American Dad!, and Kitchen Nightmares. | Local |
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