| SC: Charleston (South Carolina Direct TV) | | 2 | WCBD | Programs on NBC include: The Olympics through 2012, Miss Teen USA, The Marriage Ref, Law & Order: Criminal Intent, Saturday Night Live, America's Got Talent, Law & Order: Special Victims Unit, VeggieTales, and National Football League. | Local |
| 4 | WCIV | Programs on ABC include: The Deep End, The Emperor's New School, The Suite Life of Zack and Cody, Brothers & Sisters, FlashForward, Rose Bowl Game, The Replacements, Academy Awards, and Extreme Makeover: Home Edition. | Local |
| 5 | WCSC | Programs on CBS include: The Big Bang Theory, Tony Awards, NFL on CBS/The NFL Today, Grammy Awards, The Mentalist, Undercover Boss, Miami Trauma, Ghost Whisperer, and Gator Bowl. | Local |
| 7 | ETV | Programs on PBS include: Cyberchase, Franny's Feet, Masterpiece, Angelina Ballerina, Ask This Old House, Hometime, The New Yankee Workshop, Baking With Julia, and P.O.V.. | Local |
| 14 | CW | Programs on CW include: 90210, One Tree Hill, Smallville, America's Next Top Model, Supernatural, Gossip Girl, The Tyra Banks Show, Melrose Place, and Life Unexpected. | Local |
| 24 | WTAT | Programs on FOX include: New Year's Eve Live, Hell's Kitchen, 24, Family Guy, Lie to Me, Bones, Teen Choice Awards, Our Little Genius, and Fringe. | Local |
| 36 | WMMP | WMMP (MNT) | Local |
| SC: Columbia (South Carolina Direct TV) | | 10 | WIS | Programs on NBC include: The Olympics through 2012, Miss Teen USA, The Marriage Ref, Law & Order: Criminal Intent, Saturday Night Live, America's Got Talent, Law & Order: Special Victims Unit, VeggieTales, and National Football League. | Local |
| 19 | WLTX | Programs on CBS include: The Big Bang Theory, Tony Awards, NFL on CBS/The NFL Today, Grammy Awards, The Mentalist, Undercover Boss, Miami Trauma, Ghost Whisperer, and Gator Bowl. | Local |
| 25 | WOLO | Programs on ABC include: The Deep End, The Emperor's New School, The Suite Life of Zack and Cody, Brothers & Sisters, FlashForward, Rose Bowl Game, The Replacements, Academy Awards, and Extreme Makeover: Home Edition. | Local |
| 35 | WRLK | Programs on PBS include: Cyberchase, Franny's Feet, Masterpiece, Angelina Ballerina, Ask This Old House, Hometime, The New Yankee Workshop, Baking With Julia, and P.O.V.. | Local |
| 47 | WZRB | Programs on CW include: 90210, One Tree Hill, Smallville, America's Next Top Model, Supernatural, Gossip Girl, The Tyra Banks Show, Melrose Place, and Life Unexpected. | Local |
| 57 | WACH | Programs on FOX include: New Year's Eve Live, Hell's Kitchen, 24, Family Guy, Lie to Me, Bones, Teen Choice Awards, Our Little Genius, and Fringe. | Local |
| 63 | WKTC | WKTC (MNT) | Local |
| SC: Florence-Myrtle Beach (South Carolina Direct TV) | | 10 | WIS | Programs on NBC include: The Olympics through 2012, Miss Teen USA, The Marriage Ref, Law & Order: Criminal Intent, Saturday Night Live, America's Got Talent, Law & Order: Special Victims Unit, VeggieTales, and National Football League. | Local |
| 13 | WBTW | Programs on CBS include: The Big Bang Theory, Tony Awards, NFL on CBS/The NFL Today, Grammy Awards, The Mentalist, Undercover Boss, Miami Trauma, Ghost Whisperer, and Gator Bowl. | Local |
| 15 | WPDE | Programs on ABC include: The Deep End, The Emperor's New School, The Suite Life of Zack and Cody, Brothers & Sisters, FlashForward, Rose Bowl Game, The Replacements, Academy Awards, and Extreme Makeover: Home Edition. | Local |
| 21 | WWMB | Programs on CW include: 90210, One Tree Hill, Smallville, America's Next Top Model, Supernatural, Gossip Girl, The Tyra Banks Show, Melrose Place, and Life Unexpected. | Local |
| 31 | UNC | Programs on PBS include: Cyberchase, Franny's Feet, Masterpiece, Angelina Ballerina, Ask This Old House, Hometime, The New Yankee Workshop, Baking With Julia, and P.O.V.. | Local |
| 33 | ETV | Programs on PBS include: Cyberchase, Franny's Feet, Masterpiece, Angelina Ballerina, Ask This Old House, Hometime, The New Yankee Workshop, Baking With Julia, and P.O.V.. | Local |
| 43 | WFXB | Programs on FOX include: New Year's Eve Live, Hell's Kitchen, 24, Family Guy, Lie to Me, Bones, Teen Choice Awards, Our Little Genius, and Fringe. | Local |
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