| SC: Charleston (South Carolina Dish Network) | | 2 | WCBD | Programs on NBC include: Miss USA, The Biggest Loser, Law & Order, Law & Order: Special Victims Unit, 100 Questions, National Football League, Chuck, The Marriage Ref, and Last Call with Carson Daly. | Local |
| 4 | WCIV | Programs on ABC include: Major League Soccer, Belmont Stakes, Dancing with the Stars, The Deep End, Happy Town, ABC World News, Jimmy Kimmel Live!, Extreme Makeover: Home Edition, and Private Practice. | Local |
| 5 | WCSC | Programs on CBS include: CSI: NY, Crimetime Saturday, Rules of Engagement, The Price Is Right, The Good Wife, Sun Bowl, The Bridge, NCIS, and Undercover Boss. | Local |
| 7 | WITV | Programs on PBS include: GED Connection, Religion & Ethics Newsweekly, The Woodwright's Shop, Cyberchase, NOVA scienceNOW, Animalia, American Experience, Super Why!, and The Tavis Smiley Show. | Local |
| 24 | WTAT | Programs on FOX include: American Dad!, Bowl Championship Series, Lie to Me, Fox News Sunday, 24, COPS, The Simpsons, Glee, and Sons of Tucson. | Local |
| 36 | WMMP | WMMP (MNT) | Local |
| SC: Columbia (South Carolina Dish Network) | | 10 | WIS | Programs on NBC include: Miss USA, The Biggest Loser, Law & Order, Law & Order: Special Victims Unit, 100 Questions, National Football League, Chuck, The Marriage Ref, and Last Call with Carson Daly. | Local |
| 19 | WLTX | Programs on CBS include: CSI: NY, Crimetime Saturday, Rules of Engagement, The Price Is Right, The Good Wife, Sun Bowl, The Bridge, NCIS, and Undercover Boss. | Local |
| 25 | WOLO | Programs on ABC include: Major League Soccer, Belmont Stakes, Dancing with the Stars, The Deep End, Happy Town, ABC World News, Jimmy Kimmel Live!, Extreme Makeover: Home Edition, and Private Practice. | Local |
| 35 | WRLK | Programs on PBS include: GED Connection, Religion & Ethics Newsweekly, The Woodwright's Shop, Cyberchase, NOVA scienceNOW, Animalia, American Experience, Super Why!, and The Tavis Smiley Show. | Local |
| 47 | WZRB | Programs on CW include: Smallville, America's Next Top Model, Melrose Place, Gossip Girl, The Tyra Banks Show, Life Unexpected, 90210, The Vampire Diaries, and Supernatural. | Local |
| 57 | WACH | Programs on FOX include: American Dad!, Bowl Championship Series, Lie to Me, Fox News Sunday, 24, COPS, The Simpsons, Glee, and Sons of Tucson. | Local |
| 63 | WKTC | WKTC (MNT) | Local |
| SC: Florence-Myrtle Beach (South Carolina Dish Network) |
| 13 | WBTW | Programs on CBS include: CSI: NY, Crimetime Saturday, Rules of Engagement, The Price Is Right, The Good Wife, Sun Bowl, The Bridge, NCIS, and Undercover Boss. | Local |
| 15 | WPDE | Programs on ABC include: Major League Soccer, Belmont Stakes, Dancing with the Stars, The Deep End, Happy Town, ABC World News, Jimmy Kimmel Live!, Extreme Makeover: Home Edition, and Private Practice. | Local |
| 21 | WWMB | Programs on CW include: Smallville, America's Next Top Model, Melrose Place, Gossip Girl, The Tyra Banks Show, Life Unexpected, 90210, The Vampire Diaries, and Supernatural. | Local |
| 31 | WUNU | Programs on PBS include: GED Connection, Religion & Ethics Newsweekly, The Woodwright's Shop, Cyberchase, NOVA scienceNOW, Animalia, American Experience, Super Why!, and The Tavis Smiley Show. | Local |
| 33 | WJPM | Programs on PBS include: GED Connection, Religion & Ethics Newsweekly, The Woodwright's Shop, Cyberchase, NOVA scienceNOW, Animalia, American Experience, Super Why!, and The Tavis Smiley Show. | Local |
| 43 | WFXB | Programs on FOX include: American Dad!, Bowl Championship Series, Lie to Me, Fox News Sunday, 24, COPS, The Simpsons, Glee, and Sons of Tucson. | Local |
|
